Kidney Transplantation

About Kidney Transplant At Fortis Hospital, Mumbai

At Fortis, we routinely treat patients with end-stage renal disease, vasculitis, glomerulonephritis, HIV-related kidney disease, hereditary kidney disease and help women manage chronic kidney disease during pregnancy.
 
While innovation and experience distinguish Fortis and its professional team, the benefit to you is best represented by our consistently high ratings in patient satisfaction and patient outcomes. In other words, our transplant recipients are literally living proof of the commitment to excellence exemplified across our chain of Fortis hospitals.
 
We offer the latest treatments for adults and children in the prevention, diagnosis and treatment of chronic kidney disease and kidney disorders. Our nephrologists are leaders in innovative clinical research, contributing to major advances in the treatment of kidney disease and better outcomes for our patients.
 
Patients at Fortis receive comprehensive education about the kidney transplant process. They also will be thoroughly evaluated by our multidisciplinary team to determine whether transplantation is an appropriate treatment option. Medical tests will help the team make this determination. To ensure that you receive the best possible care, our transplant team considers and discusses all potential therapeutic options with each patient, including:
 

  • Observation (no active treatment)
  • Medical management
  • Surgery

 
Our team members are there at every step to provide guidance, discuss what to expect and answer questions. They are also available after patients have returned home to provide post-transplant counselling and any additional information and answer questions. The team also can help with follow-up care, including routine blood testing, medication evaluation and adaptation, and visits to ensure that patients are doing well.

Understanding Kidney Transplant

Renal transplant or kidney transplant, as it is commonly known, refers to the transfer of kidney from a healthy person to a patient whose kidneys have lost the capability of performing the essential process of filtration. In most cases, the diseased kidneys, located in the abdomen near the lower back, are not removed. The new kidney is positioned in the pelvic area where it is surgically connected to nearby blood vessels.

Types of Kidney Transplant

There are two types of kidney transplantation: deceased-donor (formerly known as cadaveric) and living-donor. Among these, living-donor transplantation can be further sub categorized as highly sensitized, related (ABO compatible) and non-related (ABO incompatible) kidney transplants. Living transplant donors and recipients should have matching or compatible blood types to decrease the risk of organ rejection. If you are unsure of your blood type, your doctor will review this information with you during your evaluation process.

ABO incompatible kidney transplant

In the past, if your blood contained antibodies that reacted to your donor’s blood type, the antibody reaction would immediately cause you to reject your transplant. This would prevent a successful transplant. Until recently, the only option was to identify recipient-donor transplant pairs with compatible ABO blood types.
 
Now ABO incompatible kidney transplant is possible between some recipients and living donors. The option of having a living donor with a different blood type may reduce the time on a waiting list.
 
With ABO incompatible kidney transplant, you receive medical treatment before and after your kidney transplant to lower antibody levels in your blood and reduce the risk of antibodies rejecting the donor kidney. This treatment includes:
 

  • Removing antibodies from your blood (plasmapheresis)
  • Injecting antibodies into your body that protect you from infections (intravenous immunoglobulin)
  • Providing other medications that protect your new kidney from antibodies

Highly Sensitized Transplants

Sometimes a transplant is not possible even if a potential donor’s tissue and blood types otherwise match perfectly. This is because they have a highly sensitized immune system that would attack the transplanted kidney. An innovative procedure — intravenous immunoglobulin (IVIG) therapy — is being used to give new hope in such patients. IVIG is a processed form of immunoglobulin (proteins naturally produced within the body that are natural defences against invading organisms). It is made from blood plasma. Immunoglobulin is injected into a vein to protect the patient from infection and immune diseases. IVIG therapy reduces sensitivity by adding helpful antibodies to the patient’s bloodstream and blocks their ability to attack a transplanted organ. IVIG therapy can be used successfully in both adults and children seeking kidney transplants.